Hanaa Salem Moubarak, Tarek Ahmed Essawyand Saher Sayed Mohammed,

ABSTRACT
Potassium Bromate (KBrO3) Is A Strong Oxidizing Agent Involved In Many Food And Cosmetic Industries. It Is Used Mainly As A Flourimprover. This Compound Was Found To Be Toxic To Animal And Human Body Organs And Was Classifiedas B2 (probable Human) Carcinogen And Health Organizations Started Banning It. However, It Is Still Used In Bakeries In Large Amounts. The Aim Of This Study Was To Investigate The Effect Of KBrO3 Administration On Parotid Gland Of Adult Male Albino Rats. 60 Adult Male Albino Rats Weighting ~ 200 Gm Were Divided Equally Into 3 Groups: Control, Experimental Group I (gp I) And Experimental Group II (gp II). Control Group, Received Distilled Water And The Experimental Gps. Received 62 And 123 Mg\kg KBrO3 Respectively Dissolved In Distilled Water Orally On A Daily Basis For 2 And 4 Months. Histopathological Examination Of Specimens In Experimental Groups Revealed Histological Alternations And Dysplastic Changes That Increased As Increasing The Dose And The Duration. Distended Acini With Vacuolated Cytoplasm, Nuclear Changes (hypertrophy, Pleomorphism And Hyperchromatism), Abnormal Mitotic Figures,dilated Ducts With Thin Atrophied Lining And Stagnant Secretions, Dilated Congested Blood Vessels, Fibrosisand Inflammatorycell Infiltrationwere The Main Histological Changes Observed. Immunohistochemical Results Showed Significantincrease In Immunoreactivity Of PCNA In KBrO3 Treated Groups Compared To The Control Group. In Conclusion KBrO3 Was Proved To Cause A Dose And Time Dependent Carcinogenic Effect On Parotid Salivary Gland Of Adult Male Albino Rats.